Faced with the “blind spot” of the existing cross-research of media and economy, this study first clarified the fundamental position of production discourse of Marxist political economy, combined with mediatization theory, and then pointed out that the process of media construction in the development of productive forces and production relations is economic mediatization, with media, media and media logic as the operational concepts of economic mediatization analysis, and finally demonstrated the meta-process of economic mediatization of human society through historical review. Under the cooperation of infrastructure media, economic media and information media, economic mediatization has undergone four stages: penetration, extension, change and internalization. In this process, media logic has a double-edged effect of construction and masking on economic development. Economic mediatization is a supplementary study of the “invisible relations” behind material production in Marxist political economy, and provides a new path for the development of the cross-study of media and economy and the study of mediatization society.