The research of journalism and communication in China has never been a matter of purely conceptual scope, but rather a matter of socialist theory with Chinese characteristics and national development, a practical matter of unity of knowledge and practice. The theory of socialism with Chinese characteristics, the century-long history of journalism and communication practice in China, the practice of digital and platform-based communication in China, and the “practice paradigm” shift in global media and communication research together provide a rich foundation, opportunities and new paths for the construction of an autonomous journalism and communication knowledge system in China. Building a knowledge system is a complex systematic project. The construction of China's autonomous journalism and communication knowledge system requires scholars and students to be brave, willing and adept at innovation in cross-collision, research in openness and tolerance, and truth-seeking from multiple perspectives, actively embracing real life and the entire philosophy and social sciences. The construction of the system should be based on orientation to the major topics of the discipline, to the major strategies of the country and to the major problems of practice, with practice orientation, problem orientation and value orientation as the key, and the transformation between practice, disciplines and professions as the specific path to continuously promote the transformation of Chinese and foreign theories, the transformation of practice and theory, the transformation of multidisciplinary knowledge and the transformation of mechanism and evaluation. Only based on practice, and committed to influencing the cognition and judgment of the academia and industry to the height of influencing the decision of the country, journalism and communication can have significant influence and sustainable development value and significance in the whole discipline.