Taking 305 animated films released on Mainland China from 2009 to 2018 as a research sample, this study empirically analyzes the impact of online word-of-mouth on box office of domestic and imported animated films. The results show that the volume of online wordof-mouth has a significant positive effect on the box office of both domestic and imported animated films, while the valence of online word-of-mouth can only improve the box office of imported animated films. After the first week's release of animated films, the volume of online word-of-mouth has a greater positive effect on box office of domestic animated films, while the valence of online word-of-mouth has a stronger positive effect on box office of importedanimated films. In addition, since the first week box office has a significant positive impact on the box office of domestic and imported animated films, it has become an important indicator to predict the box office of animated films. However, sequel only has significant positive impact on the box office of domestic animated films, it could be the guarantee of high box office of domestic animation films.