This paper draws on the research framework of the digital divide and explores its effects on the speed of knowledge acquisition in different educated groups with the moderating effect model, adopting the digital divide concepts of Internet access, Internet health information usage, Internet engagement, etc. The result shows that there is a positive correlation between Internet engagement and cancer knowledge, while the other two digital divide variates do not signifcantly positively in?uence cancer knowledge. However, Internet access has signifcantly narrowed the cancer knowledge gap between the groups with different education levels: compared with high educated group, low educated group can also gain more knowledge by the Internet access. Moderating effect of the other two digital divide variables are not signifcant: individuals will not get more cancer knowledge from Internet health information because of high degree of internet engagement. The result only partially supports the research hypothesis, which shows that the factors affecting people’s access to knowledge from the Internet are complex and multiple, and that the profound connotation of the digital divide needs further research in the future.