Based on Régis Debray’s theory of médiasphères, this article explored the role of maps in the context of médiation within techno-cultural ecology between the 16th century and the 17th century. On one hand, as part of knowledge mediatization, cartography along with its reading, communicating and merchandising in early modern Europe had created a new knowledge space within which geographical space of science and cultural space of ideas intertwined together. On the other, rising modern states and commercial societies took part in this process of creating knowledge space. Not only cartography and map reading have been a factor of power’s acquisition and maintenance, they also reflected internal ecology of commercial paradigm, industrial groups, trade situation, public culture and economic-societal environment. New maps and atlas have been a force médiatique, they shaped the transmission, communication and transformation of modern knowledge while creating hybrids between medium and technophenomenon, medias sphere and cultural society. The cartographic revolution combined itself with rising modern states, establishing a historical foundation for the new political geography and territorial space.