Since 1968 Chapel Hill Study, agenda-setting theory has experienced ffty-year development and stood the tests. Faced with the challenge of new media environment, agenda-setting theory has expanded its domain from 1st level, 2nd level to 3rd level - network agenda-setting. This interview with Prof. Maxwell McCombs, Prof. Donald Shaw, and Prof. David Weaver discussed the current research and mainly focuses on three aspects: agenda-setting theory in new media environment, audience action and audience psychology. In new media environment, the core concept of agenda-setting theory - transfer of salience is still essential. Meanwhile, network analysis and psychological methods provide inspiration for theorectical development. In intercultural context, agenda-setting theory still has theoretical and practical values.