The China Weekly Review is the first English periodical that was established by American professional newspapermen in Shanghai in 1917. The Review experienced three publishers and concurrent chief editors in its 32-year history. They are Thomas F. Millard, John B. Powell and his son John W. Powell. Millard, the chief founder of the Review, is the first professional journalists who came to China from western countries. He is regarded as “the founding father of American journalism in China”. Senior Powell, the other founder of the Review, is the first professionally educated American newspaperman who came to China and helped establish the Review. Led by Millard and senior Powell, lots of American professional journalists joined their effort in reporting China, which has left a precious legacy in international journalism. The Review can be seen as a turning point of great significance. It’s the first periodical that was established by professional newspapermen from the West. The Review began to present very different characteristics under the management of junior Powell, especially after the establishment of P. R. China. After much effort, junior Powell found it hard to continue the publication of Review in China. The “farewell issue” was sent to its readers in Jul. 1953. The Review became the last foreign publication, which left the mainland China.