This study used EEG technology to explore the effects of psychological perception and EEG of users of different genders on different speech rate (1.0x and 1.5x) when listening to synthetic speech news. The results showed that the female audience liked the synthetic speech news more than the male audience. When the speed of synthetic speech was 1.5 times , the male audience trusted more than female ones. At 1.0 time speed, males trusted less than females. In addition, EEG results showed that females have a higher power spectral density (PSD) than males while listening to synthetic speech. Moreover, the audience had greater cognitive load and concentration when they listening to the synthesized speech at 1.5 times speed than when listening to the synthesized speech at 1.0 time. These findings suggest that likability is not related to the speed of speech, but related to the gender of the audience. Credibility was also related to rate of speech and gender of the audience. Synthetic speech triggered greater brain activity in Females. Faster speech speed attracted more attention from the audience.